Untitled Document

PRE-MEETING SYMPOSIA

Saturday, May 31, 2008

1. Transplant Immunology for the Clinician
Transplant Immunology I: Antigen Dependent Mechanisms
Chair: James S. Allan, MD, Massachusetts General Hospital, Boston, MA
8:00 am – 8:30 am Alloimmunity and Antigen Processing
James S. Allan, MD
Massachusetts General Hospital, Boston,MA
8:30 am – 9:00 am T-cell Activation
John Iacomini, PhD
Brigham and Women's Hospital, Boston, MA
9:00 am – 9:30 am B-cell Activation
Anita S. Chong, MD
University of Chicago, Chicago, IL
9:30 am – 10:00 am Alloantibodies: Early and Late Effects in Graft Injury
Robert B. Colvin, MD
Harvard Medical School, Cambridge, MA
10:00 am – 10:30 am Coffee Break
Transplant Immunology II: Antigen Independent Mechanisms
Chair: Roslyn B.Mannon, MD, NIDDK, National Institutes of Health, Bethesda, MD
10:30 am – 11:00 am Toll-like Receptors in Solid Organ Transplantation
Daniel Goldstein, MD
Yale University School of Medicine, New Haven, CT
11:00 am – 11:30 am Chemokines and Cell Traffic
Jonathan S. Bromberg, MD, PhD
Mt. Sinai School of Medicine, New York, NY
11:30 am – 12:00 nn Effector Mechanisms Leading to Graft Destruction
Richard N. Pierson III, MD
University of Maryland, Baltimore, MD
12:00 nn – 12:30 pm Allograft Fibrosis: The Response to Inflammation
Roslyn B. Mannon, MD
NIDDK, National Institutes of Health, Bethesda, MD
12:30 pm – 1:30 pm Lunch
Transplant Immunology III: Regulation of the Alloimmune Response
Chair: John Iacomini, PhD, Brigham and Women's Hospital, Boston, MA
1:30 pm – 2:00 pm Regulatory T Cells
James F. Markmann, MD, PhD
Massachusetts General Hospital, Boston, MA
2:00 pm – 2:30 pm Co-stimulatory Pathways in Rejection and Tolerance
Mohamed Sayegh, MD
Brigham and Women's Hospital, Boston, MA
2:30 pm – 3:00 pm Memory T Cell Responses
Christian P. Larsen, MD
Emory University, Atlanta, GA
3:00 pm – 3:30 pm Coffee Break
Transplant Immunology IV: Clinical Application of Basic Science
Chair: Anthony M. Jevnikar,MD, London Health Sciences Center, London, Canada
3:30 pm – 4:00 pm Anti-donor Antibody Responses: Their Detection and Clinical Relevance
Peter Nickerson, MD
Canadian Blood Services, Manitoba, Canada
4:00 pm – 4:30 pm Immunogenicity Across Organs: A Hierarchy of Responses
Douglas J. Norman, MD
Oregon Health and Sciences University, Portland, OR
4:30 pm – 5:00 pm Tolerance – Are We Getting Close?
Robert Lechler, PhD, FRCP
Guy's, King's and St. Thomas' School of Medicine, London, United Kingdom

2. Clinical Updates
Complications of Transplantation
Chairs: Edward Cole,MD, Toronto General Hospital, Toronto, Canada and Jonah Odim,MD, PhD, MBA, National Institutes of Health, Bethesda, MD
Malignancy
8:00 am – 8:30 am Defining the Risks of Post-transplant Malignancy
Bertram L. Kasiske, MD
University of Minnesota, Minneapolis, MN
8:30 am – 9:00 am Can EBV-Related Lymphoproliferative Disease Be Prevented?
Atul Humar, MD
University of Alberta, Edmonton, Canada
9:00 am – 9:30 am Role of TOR Inhibitors in Posttransplant Neoplasia
Barry Kahan, MD, PhD
University of Texas Health Science Center, Houston, TX
9:30 am – 10:00 am Break
Metabolic Issues in Transplantation
10:00 am – 10:30 am Effects of New Onset Diabetes Mellitus on Graft and Patient Outcomes
Edward Cole, MD
Toronto General Hospital, Toronto, Canada
10:30 am – 11:00 am Role of Hepatitis C in New Onset Diabetes Mellitus in Organ Recipients
Roy D. Bloom, MD
University of Pennsylvania, Philadelphia, PA
11:00 am – 11:30 am Should Immunosuppression be Changed in Patients with New Onset Diabetes Mellitus?
Alan Wilkinson, MD
University of California, Los Angeles, Los Angeles, CA
11:30 am – 12:00 nn Insulin Resistance – A Metabolic Pathway That Contributes to Chronic Liver Injury
Graeme MacDonald, PhD, MBBS
The Princess Alexandra Hospital, Woolloongabba, Australia
12:00 nn – 1:30 pm Lunch Break
Update on Immunosuppression
Chairs: Kenneth A. Newell,MD, PhD, Emory University, Atlanta, GA and Jeffrey S. Zaltzman, MD, St.Michael's Hospital, Toronto, Canada
1:30 pm – 2:00 pm Choosing Patients for Desensitization Protocols
James M. Gloor, MD
Mayo Clinic Rochester, Rochester, MN
2:00 pm – 2:30 pm Pharmacoeconomics of Induction Antibody Therapy
Mark A. Schnitzler, PhD
Saint Louis University School of Medicine, St. Louis, MO
2:30 pm – 3:00 pm New Immunosuppressive Drugs in thePipeline
Flavio Vincenti, MD
University of California San Francisco, San Francisco, CA
3:00 pm – 3:30 pm Break
3:30 pm – 4:00 pm Cellular Assays for Monitoring Immunosuppression
Adriana Zeevi, PhD
University of Pittsburgh, Pittsburgh, PA
4:00 pm – 4:30 pm Monitoring for Post-transplant Humoral Immunity
Anil Chandraker, MB, CHB, MRC
Brigham and Women's Hospital, Boston,MA
4:30 pm – 5:00 pm Defining a State of Operational Tolerance
Kenneth A. Newell, MD, PhD
Emory University, Atlanta, GA

3. Transplant Nurse and Coordinator Course
Co-sponsored by the International Transplant Nurses Society (ITNS), NATCO, The Organization for Transplant Professionals, and the International Society of Heart and Lung Transplantation (ISHLT)
Chairs: Kathy Schwab, RN, BSN,Mayo Clinic Rochester, Rochester MN and Catherine Garvey, RN, BA, CCTC, University of Minnesota Medical Center – Fairview,Minneapolis, MN
8:30 am – 9:15 am Developing Relationships with Referring Physicians
Michael Petty, MD
University of Minnesota Medical Center – Fairview, Minneapolis, MN
9:15 am – 10:00 am Defining the High-risk Transplant Recipient from a Psychosocial Point of View
Fabienne Dobbels, PhD
Center for Health Services and Nursing Research, Katholieke Universiteit, Leuven, Belgium
10:00 am – 10:15 am Break
10:15 am – 11:00 am Patient Education
Patricia Folk, RN, BSN, CCTC
University of Pittsburgh Medical Center, Pittsburgh, PA
11:00 am – 11:45 am Quality Indicators/Dashboard
Marian O'Rourke, RN, CCTC
Tulane University Hospital and Clinic, New Orleans, LA
11:45 am – 12:30 pm Life-Work Balance
Connie White-Williams, RN, MSN
University of Alabama at Birmingham, Birmingham, AL
12:30 pm – 1:30 pm Lunch – On own
Concurrent Sessions
Liver Transplant
Chair: Patricia Folk, RN, BSN, CCTC, University of Pittsburgh Medical Center
1:30 pm – 2:15 pm Evaluation and Acceptance Criteria for the High-Risk Recipient
Dianne LaPointe Rudow, DrNP, CCTC
New York Presbyterian Medical Center, New York, NY
2:15 pm – 3:00 pm Waitlist Management
Lindsay Arnott, RN, BS, CCTC
Children's Medical Center Dallas, Dallas, TX
3:00 pm – 3:15 pm Break
3:15 pm – 4:00 pm Risk Factors/Outcomes of Using Extended Criteria Donors: Post-Operative Complications
Frank Van Gelder, RN, BSN, ECTC
University Hospital Leuven Gasthuisberg, Belgium
4:00 pm – 4:45 pm Open-space Discussion
Dianne LaPointe Rudow, DrNP, CCTC;
Lindsay Arnott, RN, BS, CCTC;
Frank Van Gelder, RN, BSN, ECTC
Kidney Transplant
Chair: Marian O'Rourke, RN, CCTC, Tulane University Hospital and Clinic, New Orleans, LA
1:30 pm – 2:15 pm Evaluation and Acceptance Criteria for the High-risk Recipient
Clare Whitaker, BSc
The Royal London Hospital, London, United Kingdom
2:15 pm – 3:00 pm Waitlist Management
Catherine Garvey, RN, BA, CCTC
University of Minnesota Medical Center-Fairview, Minneapolis, MN
3:00 pm – 3:15 pm Break
3:15 pm – 4:00 pm Risk Factors/Outcomes of Using Extended Criteria Donors: Post-Operative Complications
Lynette Fix, RN, BA, CCTC
Mayo Clinic Rochester, Rochester, MN
4:00 pm – 4:45 pm Open-space Discussion
Clare Whitaker, BSc;
Catherine Garvey, RN, BA, CCTC;
Lynette Fix, RN, BA, CCTC
Thoracic Transplant
Chair: Michael Petty, MD, University of Minnesota Medical Center-Fairview,Minneapolis,MN
1:30 pm – 2:15 pm Evaluation and Acceptance Criteria for the High-Risk Recipient
Lori Coleman, RN, CPTC
University of California, San Francisco, San Francisco, CA
2:15 pm – 3:00 pm Waitlist Management
Linda Ohler, RN, MSN, CCTC, FAAN
Virginia Commonwealth University, Arlington, VA
3:00 pm – 3:15 pm Break
3:15 pm – 4:00 pm Risk Factors/Outcomes of Using Extended Criteria Donors: Post - Operative Complications
Katherine Hoercher, RN
Cleveland Clinic – Kaufman Center for Heart Failure, Cleveland, OH
4:00 pm – 4:45 pm Open-space Discussion
Lori Coleman, RN, CPTC;
Linda Ohler, RN, MSN, CCTC, FAAN;
Katherine Hoercher, RN

4. Transplantation
Co-sponsored with the International LiverTransplantation Society (ILTS)
Background and Perspective
Chairs: Gary L. Davis, MD, Baylor University Medical Center, Dallas, TX and David C.Mulligan, MD, Mayo Clinic Hospital, Phoenix, AZ
8:00 am – 8:20 am Hepatitis C: Trends and Natural History
Edward Gane, MB/ChB, MD
New Zealand Liver Transplant Unit, Auckland, New Zealand
8:20 am – 8:40 am Current Pre-transplant Therapies for HCV Patients
James F. Trotter, MD
University of Colorado, Denver, CO
8:40 am – 9:10 am Molecular and Therapeutic Advances for Treatment of HCV
Michael R. Charlton, MD
Mayo Clinic Rochester, Rochester, MN
9:10 am – 9:30 am Hepatitis C as an Indication for Liver Transplantation
Gary A. Levy, MD
Toronto General Hospital, Toronto, Canada
9:30 am – 9:50 am Management of the Listed Patient
Gregory T. Everson, MD
University of Colorado Health Science Center, Denver, CO
9:50 am – 10:10 am Panel Discussion
10:10 am – 10:30 am Coffee Break
HCV and Liver Transplantation
Chairs: Geoffrey W.McCaughan, PhD, MBBS, Royal Prince Alfred Hospital, Sydney, Australia and Alan N. Langnas,DO,University of Nebraska Medical Center, Omaha, NE
10:30 am – 10:50 am Outcomes of Transplantation for HCV Recipients
Shawn J. Pelletier, MD
University of Michigan Health System, Ann Arbor, MI
10:50 am – 11:10 am Treatment Strategies for HCV after Transplantation
Hugo E. Vargas, MD
Mayo Clinic Hospital, Phoenix, AZ
11:10 am – 11:30 am Managing Complications of Anti-viral Therapy
Sammy Saab,MD, MPN
University of California, Los Angeles, Los Angeles, CA
11:30 am – 11:50 am HCC in HCV Recipients
Jeffrey S. Crippin, MD
Washington University School of Medicine, St Louis, MO
11:50 am – 12:10 pm Panel Discussion
12:15 pm – 1:15 pm Lunch
HCV Recurrence after Transplantation
Chairs: John J. Fung, MD, PhD, Cleveland Clinic Foundation, Cleveland, OH and Russell H.Wiesner, MD,Mayo Clinic Rochester, Rochester, MN
1:30 pm – 1:50 pm Virology of HCV Recurrence
Rajender Reddy, MD
University of Pennsylvania, Philadelphia, PA
1:50 pm – 2:10 pm Induction Therapy for Orthotopic Liver Transplantation in HCV
Michael R. Lucey, MD
University of Wisconsin Hospital and Clinics, Madison, WI
2:10 pm – 2:30 pm Ideal Immunosuppressive Protocols for HCV Recipients
Federico Villamil, MD
Fundacion Favaloro, Buenos Aires, Argentina
2:30 pm – 2:50 pm Retransplantation for HCV
Hugo R. Rosen, MD
University of Colorado, Denver, CO
2:50 pm – 3:10 pm Panel Discussion
3:10 pm – 3:30 pm Coffee Break
Recurrence Risk Factors
Chairs: Kim M. Olthoff,MD,University of Pennsylvania Hospital, Philadelphia, PA and Robert S. Brown, Jr.,MD, MPH,New York Presbyterian Hospital, New York, NY
3:30 pm – 3:50 pm Donor and Recipient Factors Implicated in Recurrence
R. Mark Ghobrial, MD, PhD
University of California Los Angeles, Los Angeles, CA
3:50 pm – 4:10 pm Should MELD Allocation be Changed to Reduce Recurrence Risk?
John R. Lake, MD
University of Minnesota,Minneapolis, MN
4:10 pm – 4:30 pm HCV Recurrence after Living Donation
Norah A. Terrault, MD, MPH
University of California San Francisco, San Francisco, CA
4:30 pm – 4:50 pm Panel Discussion

5. HRSA and OPTN: Current Issues and Initiatives
Federal Oversight and Advancement of Organ Transplantation
Chair: Virginia McBride, MPH, RN, CPTC, Health Resources and Services Administration, Rockville,MD
8:00 am – 8:30 am Federal Oversight and Advancement of Transplantation: Statutory and Regulatory Basis
James F. Burdick, MD
The Johns Hopkins Hospital, Baltimore, MD
8:30 am – 9:00 am Solid Organ Allocation, Policymaking and Professional Oversight: The Organ Procurement and Transplantation Network
Christopher J. McLaughlin
Health Resources and Services Administration, Rockville, MD
9:00 am – 9:30 am Data Analyses to Support Solid Organ Policymaking: The Scientific Registry of Transplant Recipients
Gregory Fant, PhD
U.S. Department of Health and Human Services, Rockville, MD
9:30 am – 10:00 am Public and Professional Education Activities Advancing Organ Donation
Mary Ganikos, PhD
Health Resources and Services Administration/HHS, Rockville, MD
10:00 am – 10:30 am Break
Organ Procurement and Transplant Network – Current Issues
Chair: Timothy L. Pruett, MD, University of Virginia, Charlottesville, VA
10:30 am – 11:30 am The OPTN Compliance Process
Robert S. D. Higgins, MD
Rush University Medical Center, Chicago, IL
11:00 am – 11:30 am DonorNet® – The First Year
Richard Hasz, MFS, CPTC
Gift of Life Donor Program, Philadelphia, PA
11:30 am – 12:00 nn Analyzing the Waitlist and Waitlist Mortality
Francis Delmonico, MD
Massachusetts General Hospital, Boston, MA
12:00 nn – 12:30 pm Progress Toward a New Kidney Allocation Schema
Mark D. Stegall, MD
Mayo Clinic Rochester, Rochester, MN
12:30 pm – 2:15 pm Lunch
Maximizing Donor Management via Partnerships
Chairs: Kevin O'Connor, MS, New England Organ Bank, Newton, MA
2:15 pm – 2:45 pm Regional and Donation Service Areas Variation in Number of Organs Transplanted Per Donor
 James F. Burdick, MD
Health Resources and Services Administration, Rockville, MD
2:45 pm – 3:15 pm Linking Donor Management Targets to Organs Transplanted Per Donor – The Impact of Donor Management “Bundles”
Diane Brockmeier, RN, BSN, MA
Mid-America Transplant Services, St. Louis, MO
3:15 pm – 3:45 pm Utilizing Advanced Clinical Practitioners to Implement Donor Management Protocols
Nader Habashi, MD
University of Maryland, Baltimore, MD
3:45 pm – 4:00 pm Break
4:00 pm – 4:30 pm Conducting Donation Service Area-Based Organ Specific “Mini-Collaboratives”
Susan Gunderson, MHA
LifeSource, Minneapolis, MN
4:30 pm – 5:00 pm Identifying the Elements of a Comprehensive Donor Management Protocol
David Powner, MD, FCCP, FCCM
University of Texas, Houston, TX
5:00 pm – 5:30 pm Sleeping With the Enemy: Effective Inter-program Conflict Resolution at Your Organ Procurement Organizations to Promote Donation
William Bry, MD
California Pacific Medical Center, San Francisco, CA

6. Updates for the Clinician-Scientist
Highlights and What's New From Recent Clinical Trials
Chair: Yolanda T. Becker,MD, University of Wisconsin Hospital and Clinics,Madison, WI
8:00 am – 8:30 am New Trends in Designing Trials and Reading the Literature: When Is Noninferior Superior?
Herwig-Ulf Meier-Kriesche, MD
University of Florida, Gainesville, FL
8:30 am – 9:00 am Highlights ofWhat's New in Kidney Trials
Stephen Tomlanovich,MD
University of California, San Francisco, San Francisco, CA
9:00 am – 9:30 am Highlights of What's New in Liver Trials
Paul Martin, MD
Mt. Sinai School of Medicine, New York, NY
9:30 am – 10:00 am Highlights of What's New in Heart and Lung Trials
Richard N. Pierson III, MD
University of Maryland, Baltimore, MD
10:00 am – 10:30 am Coffee Break
Management of Clinical Problems Common to Solid Organ Transplants – Highlights of New Management Approaches
Chair: Steven Paraskevas,MD, PhD, McGill University Health Centre,Montreal, Canada
10:30 am – 11:00 am Translating Drug Therapies to the Clinic: The Essentials of Pharmacokinetics to Pharmacogenomics
Gilbert Burckart, PharmD
University of Southern California, Los Angeles, CA
11:00 am – 11:30 am Management of Renal Dysfunction in Non-renal Transplants with Renal Dysfunction – What's New?
Sandra M. Cockfield, MD
University of Alberta, Edmondton, Canada
11:30 am – 12:00 nn The Major Viral Diseases and the Basics of their Management in Transplantation
Emily A. Blumberg, MD
Hospital of the University of Pennsylvania, Philadelphia, PA
12:00 nn – 12:30 pm Standard Criteria to Extended Criteria to Donors after Cardiac Death: Managing with More Difficult Donors
Yolanda T. Becker, MD
University of Wisconsin, Madison, WI
12:30 pm – 1:30 pm Lunch
Updates in Topical Areas of Basic Research
Chair: Xian Li,MD, PhD, Beth Israel Deaconess Medical Center, Boston, MA
2:00 pm – 2:30 pm Tolerance Induction: A Fresh Look at the Regulation of Regulatory Cells
Xian Li, MD, PhD
Beth Israel Deaconess Medical Center, Boston, MA
2:30 pm – 3:00 pm Innate Immunity and Ischemia Reperfusion Injury – Can It Really be Modified in Transplantation?
Jerzy Kupiec-Weglinski, MD, PhD
University of California, Los Angeles, Los Angeles, CA
3:00 pm – 3:30 pm Accommodation vs. Tolerance in Transplantation
Jeffrey L. Platt, MD
Mayo Clinic Rochester, Rochester, MN
3:30 pm – 4:00 pm Break
4:00 pm – 4:30 pm Xenotransplantation: A Myth, a Reality or Tool to Understand Allotransplantation?
Allan D. Kirk, MD, PhD
Emory University, Atlanta, GA
4:30 pm – 5:00 pm What Should We be Doing for Chronic Rejection?
Stuart J. Knechtle, MD
University of Wisconsin Hospital and Clinics, Madison, WI
5:00 pm – 5:30 pm Future Hot Areas for Basic Transplant Research
Roundtable Discussion with Session Speakers

HALF-DAY SESSIONS

7. Pediatric Transplantation
Co-sponsored by the International Pediatric Transplantation Association (IPTA)
Session I: Renal Dysfunction in Extra-renal Transplantation
Chairs: Simon P. Horslen, MB, ChB, Children's Hospital and Regional Medical Center, Seattle,WA and Nancy D. Bridges, MD, NIAID, Rockville,MD
1:30 pm – 1:50 pm Quantifying the Problem
Brian Feingold, MD
Children's Hospital of Pittsburgh, Pittsburgh, PA
1:50 pm – 2:10 pm Monitoring and Predicting Late Renal Dysfunction
Guido Filler, MD, PhD
Children's Hospital, London Health Center, London, Canada
2:10 pm – 2:30 pm When and How to Prevent the Problem?
Vicky Ng, MD
Hospital for Sick Children, Toronto, Canada
2:30 pm – 2:50 pm Late Kidney Transplantation after Prior Non-renal Transplantation
William Mahle, MD
Emory University, Atlanta, GA
2:50 pm – 3:30 pm Roundtable Discussion
3:30 pm – 4:00 pm Break
Session II: The HLA Sensitized Candidate and Recipient
Chairs: Ruth A.McDonald,MD, Children's Hospital and Regional Health Center, Seattle,WA and J. Richard Thistlethwaite, Jr.,MD, University of Chicago, Chicago, IL
4:00 pm – 4:20 pm Do Desensitization Protocols Really Work?
James M. Gloor, MD
Mayo Clinic Rochester, Rochester, MN
4:20 pm – 4:40 pm Strategies for Transplanting Across a Positive Cross-Match
Anne Dipchand, MD, FRCPC
The Hospital for Sick Children, Toronto, Canada
4:40 pm – 5:00 pm Why is Antibody Mediated Graft Damage not Universal with a Positive Cross-Match?
Steven A.Webber, MBChB Children's Hospital of Pittsburgh, Pittsburgh, PA
5:00 pm – 5:30 pm Roundtable Discussion

8. Infectious Disease
Practical Aspects of Transplant ID:A Case-based State-of-the-Art Update
Chairs: Jay A. Fishman, MD,Massachusetts General Hospital, Boston, MA and Michael G. Ison, MD, Northwestern University, Chicago, IL
2:00 pm – 2:30 pm Donor-Derived Infection: State-of-the-Art Jay A. Fishman, MD
Massachusetts General Hospital, Boston, MA
2:30 pm – 3:00 pm Controversies in Management of BK Viremia
Hans H. Hirsch, MD, MSc, Institute for Medical Microbiology, Basel, Switzerland
3:00 pm – 3:30 pm Cryptococcal Meningitis and CNS Infections in Transplant Patients
Nina Singh, MD
Veterans Affair Medical Center, Pittsburgh, PA
3:30 pm – 4:00 pm Break
4:00 pm – 4:30 pm Technical Complications in Split Liver and Living Donor Liver Transplant
Shimul Shah,MD
University of Massachusetts,Worcester,MA
4:30 pm – 5:00 pm Respiratory Virus Infection Posttransplant
Michael G. Ison, MD
Northwestern University, Chicago, IL
5:00 pm – 5:30 pm Roundtable Discussion